METHOD OF PRODUCING BIOCOMPOSITE BASED ON AIRGEL OF BACTERIAL CELLULOSE HAVING HAEMOSTATIC PROPERTIES Russian patent published in 2020 - IPC A61K35/74 A61K47/36 A61L15/28 A61L15/18 C12N1/20 A61P7/04 

FIELD: biotechnology; medicine.

SUBSTANCE: invention refers to biotechnology and medicine, namely to a method for producing a biocomposite based on airgel of bacterial cellulose having haemostasis properties. Method comprises producing a gel film of bacterial cellulose by culturing a strain of bacteria Gluconacetobacter sucrofermentans VKPM V-11267 in static conditions on a medium with molasses, separation of obtained gel film of bacterial cellulose from culture medium and its cleaning, mechanical grinding of purified gel film of bacterial cellulose for 10 minutes, production of hydrogel a) bacterial cellulose-chitosan in ratios of 80:20 by mixing 2 % chitosan solution in 1 % acetic acid, bacterial cellulose hydrogel, 25 % glutaric aldehyde, with addition of sodium fusidine in combination with one or more additional components, or b) bacterial cellulose:chitosan:gelatine:transglutaminase in ratio of 5:5:15:5 respectively, with addition of sodium fusidine in combination with one or more additional components, wherein the additional components are selected from physiologically active polyphenolic compounds - dehydroquercetin or resveratrol, low-molecular peptides - tinrostyma, and/or coagulation factors - thrombin or transglutaminase, obtaining airgel by freezing in a low-temperature refrigerator for a day and then performing lyophilic drying.

EFFECT: invention provides wider range of wound coatings based on airgel of bacterial cellulose with enhanced haemostatic properties and antimicrobial action.

1 cl, 16 ex