FIELD: chemistry.
SUBSTANCE: invention relates to 1-sulfonyl-2-(diphenylphosphoryl)pyrrolidines of formula I, having cytotoxic action on cancer cells. In the formula I R1=Ph, R2=Me (a); R1=R2=Ph (b). Invention also relates to a method of producing compounds of formula I. Method involves reacting 1-sulphonyl-2-ethoxypyrrolidines of the general formula given below, for which R = Me, Ph, with excess of diphenylchlorophosphine in the presence of acetic acid in a suitable solvent at room temperature until completion of the reaction and extraction of the end product using known methods.
.
EFFECT: obtained compounds selectively suppress growth of cancer cells with low or no toxic effect on normal cells.
4 cl, 1 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| 2-ARYL-1,3-THIAZOLIDINE-4-CARBOXYLIC ACIDS WITH ANTI-TUMOUR ACTIVITY | 2015 |
|
RU2630775C2 |
| DIMETHYL 7-METHYL-2-(PYRROLIDINE-1-yl)-4-PHENYLPYRROLO[2,1-ƒ][1,2,4]TRIAZINE-5,6-DICARBOXYLATE AND DIMETHYL 7-METHYL-2-(4-R-PHENYL)-4-(4-R-PHENYL)PYRROLO[2,1-ƒ][1,2,4]TRIAZINE-5,6-DICARBOXYLATES EXHIBITING ANTIVIRAL ACTIVITY | 2021 |
|
RU2790376C1 |
| DISPIROINDOLINONES BASED ON RHODANINES AS P53-MDM2 INHIBITORS OF PROTEIN-PROTEIN INTERACTION | 2019 |
|
RU2730286C1 |
| DERIVATIVES OF 1,2,3,4-TETRAHYDROPYRIDO[4,3-b]INDOLE-CONTAINING PHENOTHIAZINES AS INHIBITORS OF CHOLINESTERASES AND BLOCKERS OF SEROTONIN RECEPTORS 5-HT, METHODS OF OBTAINING THEIR CHLOROHYDRATES AND BASED ON THEM PHARMACEUTICAL PREPARATION | 2013 |
|
RU2530881C1 |
| NEW STERICALLY HINDERED PHENOLS CONTAINING BENZOFUROXAN FRAGMENTS WITH ANTITUMOR ACTIVITY | 2022 |
|
RU2796810C1 |
| AGENT POSSESSING CYTOTOXIC ACTIVITY | 2019 |
|
RU2714932C1 |
| METHOD FOR PREPARING AMMONIUM SALTS OF 3-AMINO-8-HYDROXY-1,6-DIOXO-4-CYANO-2,7-DIAASPIRO [4,4] NON-3-EN-2-IDS | 2016 |
|
RU2631856C1 |
| 4-(2,4-DIMETHOXYPHENYL)-2-(2-HYDROXYPHENYL)-5,6-DIHYDRO-4N-BENZO[H]CHROMENE-3-CARBOXYLIC ACID, HAVING CYTOTOXIC ACTIVITY | 2019 |
|
RU2707972C1 |
| SUBSTITUTED 3-PYRIDYL-4-ARYLPYRROLES AND THERAPEUTIC AND PROPHYLACTIC METHODS ASSOCIATED WITH THEM | 2000 |
|
RU2238940C2 |
| APPLICATION OF A TRICYCLIC SULPHUR-CONTAINING DERIVATIVE OF 1,2-DIHYDROQUINOLINE FOR INHIBITING THE REPLICATION OF BETACORONAVIRUSES, INCLUDING SARS-COV-2 | 2021 |
|
RU2780247C1 |
