USE OF VITAMINS AND GENES AND VITAMINS METABOLISM PROTEINS TO PRODUCE RECOMBINANT PROTEIN IN MAMMALIAN CELLS Russian patent published in 2020 - IPC C12N15/63 C07K14/705 C12N15/67 

FIELD: biotechnology.

SUBSTANCE: invention represents eukaryotic expression systems and methods of selecting mammalian cell lines which produce target proteins, such as therapeutic proteins. Said systems and methods facilitate simple and fast selection of cells mediating high levels of recombinant protein production.

EFFECT: said systems and methods reduce the effort and time required to provide access to the new therapeutic protein for patients, as well as increase cell productivity in the bioreactor.

32 cl, 22 dwg, 4 tbl