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2 741 124

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IPC

G02B30/10(2020-01-01)

G01N1/44(2006-01-01)

G01N23/04(2006-01-01)

C12N7/01(2006-01-01)

G21K7/00(2006-01-01)

C12R1/93(2006-01-01)

(21) (22)

Application

2020132185, 2020-09-30

(24)

Start date

2020-09-30

(22)

Actual filing date

2020-09-30

(45)

Published

2021-01-22

(72)

Inventor

Samygina Valeriya RolanovnaPichkur Evgenij BorisovichKonarev Petr ValerevichVorovich Mikhail FridrikhovichIshmukhametov Ajdar AjratovichEgorov

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Issledovatelskij Tsentr Institut"

METHOD OF ASSESSING THE QUALITY OF A FLAVIVIRUS SAMPLE TO OBTAIN A THREE-DIMENSIONAL STRUCTURE USING A FREE ELECTRON LASER Russian patent published in 2021 - IPC G02B30/10 G01N1/44 G01N23/04 C12N7/01 G21K7/00 C12R1/93

Abstract RU 2741124 C1

FIELD: biology.

SUBSTANCE: invention relates to biology. Disclosed is a method of assessing the quality of a flavivirus sample to obtain a three-dimensional structure using free electron lasers, involving separating a solution containing flavivirus particles into three portions, where the first and second portions are scanned using a transmission electron microscope, wherein the second portion is subjected to vitrification, and a third portion is placed in an X-ray quartz capillary with subsequent determination of particle size distribution by small-angle X-ray scattering.

EFFECT: this method provides sampling of flaviviruses corresponding to the necessary criteria for further experiments with them.

8 cl

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RU 2 741 124 C1

Authors

Samygina Valeriya Rolanovna

Pichkur Evgenij Borisovich

Konarev Petr Valerevich

Vorovich Mikhail Fridrikhovich

Ishmukhametov Ajdar Ajratovich

Egorov

Dates

2021-01-22—Published

2020-09-30—Filed