FIELD: biotechnology.
SUBSTANCE: present invention relates to biotechnology, in particular to recombination signal sequences originating from E. coli and can be used for recombinant protein production in E. coli. The invention also relates to a fused protein containing this signal sequence, to a recombinant protein and to methods for producing said recombinant protein.
EFFECT: invention enables reduction of the viscosity of host cell broth of E. coli where recombinant antigen binding protein is expressed as well as reduction of the basic expression of recombinant antigen binding protein expressed by host cell broth E. coli while cultivating host cells under pre-induction conditions.
19 cl, 5 dwg, 7 tbl, 5 ex
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