FIELD: silicone hydrogels.
SUBSTANCE: invention relates to silicone hydrogels that are more biocompatible than current ocular materials. A silicone hydrogel obtained from a mixture of reactive monomers contains: a) from 1 to 15% by weight of at least one acyclic polyamide selected from the group consisting of poly(N-vinyl-N-alkylacetamide), poly(N-vinylpyrrolidone), their copolymers and mixtures; b) at least one first monofunctional hydroxyl-substituted linear poly(disubstituted siloxane) having 4 to 8 siloxane repeating units; c) at least one second hydroxyl-substituted poly(disubstituted siloxane) selected from the group consisting of monofunctional hydroxyl-substituted linear poly(disubstituted siloxanes) having 10 to 200 or 10-100 siloxane repeating units; d) 5 to 35 wt% of at least one hydrophilic monomer selected from the group consisting of (meth)acrylate monomers, (meth)acrylate amide monomers, N-vinyl amide monomers; where the first monofunctional hydroxyl-substituted linear poly(disubstituted siloxane) and the second monofunctional hydroxyl-substituted linear poly(disubstituted siloxane) are present in concentrations in the mixture of reactive monomers in a total concentration from 40 to 70 wt.%. The wt% ratio. of all the first hydroxyl-substituted linear poly(disubstituted siloxanes) to wt.% of all of the second hydroxyl-substituted poly(disubstituted siloxanes) is 0.4-1.3 or 0.4-1.0.
EFFECT: silicone hydrogels demonstrate a desirable balance of properties including clarity, oxygen permeability, wettability, and desired protein uptake.
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