FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, specifically to the production of recombinant FSH (follicle-stimulating hormone), including α-2,3- and α-2,6-sialation, and can be used in medicine. The resulting FSH, wherein 80% or more of the total FSH sialation is α-2,3-sialation and 5% to 20% of the total FSH sialation is α-2,6-sialation.
EFFECT: resulting FSH can be effectively used for controlled ovarian stimulation and ovulation induction in in vitro fertilization (IVF) techniques.
6 cl, 13 dwg, 11 ex
Title | Year | Author | Number |
---|---|---|---|
RECOMBINANT FOLLICLE-STIMULATING HORMONE (FSH) CONTAINING ALPHA-2,3- AND ALPHA-2,6-SYALILATION | 2009 |
|
RU2682270C2 |
RECOMBINANT FOLLICLE-STIMULATING HORMONE (FSH) CONTAINING ALPHA-2, 3- AND ALPHA-2, 6-SYALILATION | 2009 |
|
RU2537268C2 |
COMPOSITION FOR CONTROLLED OVARIAN STIMULATION | 2012 |
|
RU2613324C2 |
COMPOSITION FOR CONTROLLED OVARIAN STIMULATION | 2012 |
|
RU2739037C2 |
PHARMACEUTICAL PREPARATION CONTAINING RECOMBINANT HUMAN CHORIONIC GONADOTROPIN | 2010 |
|
RU2588650C2 |
PHARMACEUTICAL PREPARATION CONTAINING RECOMBINANT HCG (HUMAN CHORIONIC GONADOTROPIN HORMONE) | 2010 |
|
RU2724528C2 |
COMPOSITION FOR TREATING INFERTILITY | 2016 |
|
RU2704252C2 |
METHOD FOR PRODUCING SIALIC ACID-CONTAINING SUGAR CHAIN | 2012 |
|
RU2597975C2 |
METHOD FOR PREPARING ANTIBODIES HAVING IMPROVED PROPERTIES | 2011 |
|
RU2604811C2 |
CELL LINE HUFSHIK RELEASING RECOMBINANT HUMAN FOLLICLE-STIMULATING HORMONE | 2012 |
|
RU2502798C2 |
Authors
Dates
2021-03-29—Published
2018-11-08—Filed