METHOD FOR MAKING (S)-N-(5-((R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDIN-1-YL)-PYRAZOLO[1,5-A]PYRIMIDIN-3-YL)-3-HYDROXYPYROLIDINE-1-CARBOXAMIDE AND ITS SALTS Russian patent published in 2021 - IPC C07D487/04 A61K31/519 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a process for the preparation of a compound of Formula I or its salt. The method includes the following steps: (a) providing an isolated compound of Formula 13; (b) obtaining a salt of a compound of Formula 13 on an optional basis; (c) treating a compound of Formula 13 or its salt with a compound of Formula 14 or its salt to obtain a compound of Formula I; (d) obtaining a salt of a compound of Formula I. X in Formula 13 is a halogen, C₁-C₆ alkoxy, C₆-C₁₀ aryloxy, or a 5-membered heteroaryl containing at least one nitrogen atom directly bonded to C=O of a compound of Formula 13 each of which is optionally substituted with one or more substituents independently selected from the group consisting of C₁-C₆ alkyl, C₁-C₆ haloalkyl, a halogen, CN, OH, C₁-C₆ alkoxy and NR¹R² where each of R¹ and R² is independently selected from hydrogen and C₁-C₆ alkyl.

EFFECT: method allows more efficiently obtaining a compound of Formula I. The invention also relates to processes for the preparation of a compound of Formula 13.

27 cl, 3 ex