METHOD FOR PREDICTING RISK OF DEVELOPING COMPLICATIONS IN BILIARY HYPERTENSION DEPENDING ON METHOD OF TREATMENT Russian patent published in 2021 - IPC A61B5/00 G01N33/49 G01N33/50 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to oncology, and can be used for predicting the risk of developing complications in biliary hypertension, depending on the method of treatment. The risk factors are defined as: Alanine aminotransferase (ALT), Albumin (Alb), Amylase (Am), Aspartate aminotransferase (ACT), Bilirubin (Bil), Gammaglutamyltransferase (GGT), Hematocrit (Hemat), Hemoglobin (Hem), Platelets (PLT), Alkaline phosphatase (ALP), Leukocytes (Leu), Past liver diseases (Pd), Blood transfusion (Bt), Treatment of jaundice (Tj). The prognostic coefficient PC is calculated by the formula PC = -2.3427 + (0.3692*Leu) + (-0.3201*Hem) + (0.3298*Hemat) + (0.2629*PLT) + (-0, 3137*ACT) + (0.4168*ALT) + (-0.1583*ALP) + (0.2349*Bil) + (-0.3655*Alb) + (1.0557*Am) + (-0.4317*GGT) + (0.2885*Tj) + (1.4609*Pd) + (4.0881*Bt). Indicators of the blood values are converted to a cipher. Leukocytes: below 4 - 1 point, from 4 to 9 - 0 points, from 9 to 15 - 2 points. Hemoglobin: below 70 - 3 points, from 70 to 90 - 2 points, from 90 to 121 - 1 point, from 121 to 160 - 0 points, above 160 - 1 point. Hematocrit: below 35 - 2 points, from 35 to 50 - 0 points, above 50 - 1 point. Platelets: below 180 - 2 points, from 180 to 360 - 0 points, above 360 - 1 point. ACT: below 31 - 1 point, from 31 to 47 - 0 points, from 47 to 200 - 1 point, from 200 to 500 - 2 points, above 500 - 3 points. ALT: below 31 - 1 point, from 31 to 45 - 0 points, from 45 to 200 - 1 point, from 200 to 500 - 2 points, above 500 - 3 points. ALP: below 20 - 1 point, from 20 to 130 - 0 points, from 130 to 258 - 1 point, from 258 to 800 - 2 points, above 800 - 3 points. Bilirubin: below 3.4 - 1 point, from 3.4 to 21 - 0 points, from 21 to 100 - 1 point, from 100 to 200 - 2 points, from 200 to 300 - 3 points, from 300 to 400 - 4 points, from 400 to 500 - 5 points, above 500 - 6 points. Albumin: less than 35 - 2 points, from 35 to 52 - 0 points, above 52 - 1 point. Amylase: below 10 - 1 point, from 10 to 100 - 0 points, from 100 to 150 - 1 point, from 150 to 200 - 2 points, from 200 to 500 - 3 points, above 500 - 4 points. GGT: below 6 - 1 point, from 6 to 71 - 0 points, above 71 - 2 points. Treatment of jaundice: puncture drainage - 1 point, endoscopic stenting - 2 points, surgical - 3 points. Absence of instances of blood transfusion, past liver diseases in the anamnesis is estimated at 0 points, wherein presence thereof is estimated at 1 point and considered as presence of a risk factor. If the PC value is less than -1.5635, a low risk, and at the PC value of -1.5635 and more, a high risk of complications is predicted.

EFFECT: method allows improving the results of application of various methodologies of unloading the biliary tract in patients with mechanical and mixed forms of jaundice of various etiopathogenesis by determining the risk factors of developing complications in biliary hypertension, depending on the method of treatment, through construction of a mathematical risk estimation model using sequential statistical analysis.

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