NEW DERIVATIVES OF EREMOMYCIN AMIDE AND APPLICATION THEREOF FOR TREATING BACTERIAL INFECTIONS Russian patent published in 2021 - IPC A61K38/14 C07K9/00 A61P31/04 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to the pharmaceutical industry and pertains to a derivative of pharmaceutically acceptable salts of eremomycin amide containing an optionally substituted aryl radical linked by an alkylaminoalkyl linker to a nitrogen atom of the C-terminal amide group of eremomycin amide, salt hydrates corresponding with the formula, and to a medical application thereof for treating infections caused by gram-positive bacteria.

wherein Ar stands for aryl selected from phenyl, biphenyl or naphthyl, optionally substituted with one to five substituents independently selected from C1-6alkyl, C1-6alkylthio, C1-6alkoxy, halogen, haloC1-6alkyl, haloC1-6alkylthio, haloC1-6alkoxy group, m independently has a value of 1 to 2, n independently has a value of 1 to 3.

EFFECT: creation of an antibacterial compound applicable against strains of pathogens, susceptible and resistant to glycopeptides, while maintaining the solubility of the antibiotic in aqueous pharmaceutically acceptable media for treating severe antibiotic-resistant bacterial infections, including those caused by MRSA, GISA and VRE strains.

4 cl, 3 tbl, 36 ex