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2 753 479

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IPC

C07D207/50(2006-01-01)

A61K31/4015(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2020133666, 2020-10-14

(24)

Start date

2020-10-14

(22)

Actual filing date

2020-10-14

(45)

Published

2021-08-17

(72)

Inventor

Bojchuk Sergej VasilevichIgidov Nazim MusabekovichZykova Svetlana SergeevnaGalembikova Ajgul RafikovnaAukhadieva Aida MaratovnaBikinieva Firyuza FanisovnaNurgatina Ilmira IlyazovnaGankova Kseniya LeonidovnaShustov Maksim Vadimovich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennaya Farmatsevticheskaya Akademiya" Ministerstva Zdravookhraneniya Rossijskoj FederatsiiFederalnoe Gosudarstvennoe Byudzhetnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Meditsinskij Universitet" Ministerstva Zdravookhraneniya Rossijskoj Federatsii

2-AMINO-1-BENZAMIDO-5-[2-(NAPHTHALENE-1-YL)-2-OXOETHYLIDENE]-4-OXO-4,5-DIHYDRO-1H-PYRROLE-3-CARBOXAMIDE EXHIBITING CYTOTOXIC AND PROAPOPTOGENIC PROPERTIES AGAINST HUMAN SOLID TUMOUR CELLS, INCLUDING THOSE RESISTANT TO CHEMOTHERAPEUTIC AGENTS Russian patent published in 2021 - IPC C07D207/50 A61K31/4015 A61P35/00

Abstract RU 2753479 C1

FIELD: medicine.

SUBSTANCE: invention relates to a new 2-amino-1-benzamido-5-[2-(naphthalene-1-yl)-2-oxoethylidene]-4-oxo-4,5-dihydro-1H-pyrrole-3-carboxamide by the formula I, exhibiting cytotoxic and proapoptogenic properties against human solid tumor cells, including those resistant to chemotherapeutic agents.

EFFECT: new compound exhibiting antitumoral activity and low toxicity is obtained.

1 cl, 3 dwg, 2 tbl

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RU 2 753 479 C1

Authors

Bojchuk Sergej Vasilevich

Igidov Nazim Musabekovich

Zykova Svetlana Sergeevna

Galembikova Ajgul Rafikovna

Aukhadieva Aida Maratovna

Bikinieva Firyuza Fanisovna

Nurgatina Ilmira Ilyazovna

Gankova Kseniya Leonidovna

Shustov Maksim Vadimovich

Dates

2021-08-17—Published

2020-10-14—Filed