METHOD FOR PREDICTING THE DEVELOPMENT OF A SEVERE COURSE OF NEONATAL DISTRIBUTIVE SHOCK IN VERY PREMATURE INFANTS WITH A BIRTH WEIGHT OF LESS THAN 1500 G Russian patent published in 2021 - IPC A61B5/87 G01N33/68 A61B5/16 A61M16/12 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to neonatology and pediatrics, and can be used to predict the severe course of neonatal distributive shock in premature infants weighing less than 1500 g at birth. The maximum oxygen concentration in the oxygen-air mixture (FiO₂), the β-arrestin-2 content in the peripheral venous blood, the pain level according to the EDIN6 scale. Calculate the prognostic index D by the formula: D = 0,114328 х А1 + 0,835339 х А2 – 2,87503 х А3 – 2,9615 х А4 – 31,2001, where: A1 is the time of primary resuscitation and stabilization of the newborn in the delivery room, min; A2 is the maximum oxygen concentration in the oxygen-air mixture (FiO2) in the first day of life, %; A3 us the content of β-arrestin-2 in peripheral venous blood in the first day of life, ng/ml; A4 is the pain level on the EDIN6 scale in the first day of life, points; 31,2001 - CONSTANT. When D is more than 0, the development of a severe course of neonatal distributive shock in the early neonatal period is predicted. If D is less than 0, it is judged that there is no development of a severe course of neonatal distributive shock in the early neonatal period.

EFFECT: method provides the ability to predict the development of a severe course of neonatal distributive shock in deeply premature infants weighing less than 1500 g at birth by determining the time of primary resuscitation and stabilization of the newborn in the delivery room in the first day of life, the maximum oxygen concentration in the oxygen-air mixture (FiO₂), β-arrestin-2 in peripheral venous blood, pain level on the EDIN6 scale and calculating the prognostic index using a mathematical apparatus, which makes it possible to distinguish among premature newborns weighing less than 1500 g a risk group for the formation of a severe course of neonatal shock and timely carry out preventive and therapeutic measures in these children.

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