METHOD FOR PREDICTING A REDUCTION IN THE RESERVE CAPABILITIES OF THE IMMUNE HOMEOSTASIS IN PEOPLE WITH AN EXPERIENCE OF LIVING AND WORKING IN THE ARCTIC CONDITIONS LONGER THAN 10 YEARS Russian patent published in 2021 - IPC G01N33/48 

FIELD: medicine.

SUBSTANCE: invention relates to the field of physiology, immunology, laboratory diagnostics, pathophysiology, and is intended for predicting a reduction in the reserve capabilities of the immune homeostasis in people with an experience of living and working in the Arctic conditions longer than 10 years. The content of CD95⁺ lymphocytes with apoptosis receptors and CD71⁺ lymphocytes with transferrin receptors is determined in the peripheral venous blood of the examined persons. If the content of each of the CD95⁺ and CD71⁺ lymphocytes is more than 0.5∙10⁹ cl/l, a parallel examination of the phenotypic structure of the CD10⁺ lymphocytes is conducted. If the value of the CD10⁺ lymphoproliferation level is less than 0.4∙10⁹cl/l, a pronounced immune imbalance is considered to be formed and a reduction in the reserve capabilities of the immune homeostasis is predicted in people with an experience of living and working in the Arctic conditions longer than 10 years.

EFFECT: invention provides a possibility to conduct rapid screening diagnostics, reduce the time and simplify the methods for predicting the risk of forming a reduction in the reserve capabilities of immune regulation manifested in the early development of secondary ecologically dependent immunodeficiencies, a predisposition to chronic diseases, early biological aging.

1 cl, 3 ex