FIELD: chemistry.
SUBSTANCE: invention relates to a method for producing 8-(alkylamino)-9-aroyl-6-(2-hydroxyphenyl)-1,3-dicyclohexyl-1,3,6-triazaspiro [4.4]nona-8-ene-2,4,7-triones, which consists in the fact that 3-aroylpyrrolo [2,1-c][1,4]benzoxazine-1,2,4-trions are subjected to sequential interaction with dicyclohexylurea, isopropylcarbodiimide or dicyclohexylcarbodiimide in an inert aprotic solvent, followed by thermolysis obtained compounds with further isolation of target products, according to the scheme
,
where I , III: Ar=C6H4Cl-4 (а); Ar=C6H4OMe-4 (б); IV: Alk=(СН3)2СН; V: Alk=С6Н13; VI, VIII: Ar=C6H4Cl-4, Alk=(СН3)2СН (а); Ar=C6H4OMe-4, Alk=(СН3)2СН (б); VII, IX: Ar=C6H4Cl-4, Alk=С6Н13 (а); Ar=C6H4OMe-4, Alk=С6Н13 (б).
EFFECT: method has been developed for obtaining new compounds that can be used as starting products for the synthesis of new heterocyclic systems and drugs in pharmacology.
1 cl, 1 tbl, 7 ex
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