IN VITRO DIFFERENTIATION OF PLURIPOTENT STEM CELLS INTO PANCREATIC ENDODERMAL CELLS (PEC) AND ENDOCRINE CELLS Russian patent published in 2022 - IPC C12N5/71

Abstract RU 2764465 C1

FIELD: biology; medicine.

SUBSTANCE: present invention relates to the field of cell biology and medicine, in particular to methods for producing insulin-secreting beta cells sensitive to glucose in the blood. To implement these methods, endocrine cells secreting hormones that simultaneously express INS and NKX6.1 are used. These endocrine cells are transplanted to the subject, and they mature in vivo.

EFFECT: present invention makes it possible to minimize the loss of the resulting cells, thereby increasing their yield.

15 cl, 107 dwg, 24 ex

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RU 2 764 465 C1

Authors

Agulnik, Alan

D'Amur, Kevin

Dates

2022-01-17—Published

2020-10-05—Filed