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(19)

RU

(11)

2 752 499

(13)

C2

(51)

IPC

C12N5/71(2010-01-01)

(21) (22)

Application

2019101200, 2017-06-14

(24)

Start date

2017-06-14

(22)

Actual filing date

2017-06-14

(45)

Published

2021-07-28

(72)

Inventor

Rieck, SebastianRezania, Alireza

(73)

Holder

Janssen Biotech, Inc.

GENERATION OF FUNCTIONAL BETA CELLS DERIVED FROM HUMAN PLURIPOTENT STEM CELL, DEMONSTRATING REACTION IN FORM OF GLUCOSE-DEPENDENT MITOCHONDRIAL RESPIRATION AND TWO-PHASE INSULIN SECRETION Russian patent published in 2021 - IPC C12N5/71 

Abstract RU 2752499 C2

FIELD: biotechnology.

SUBSTANCE: method for bringing an immature pancreatic beta cell to a mature pancreatic beta cell expressing PDX1, NKX6.1, MAFA, UCN3 and SLC2A1 is proposed. In addition, a method for differentiating pluripotent stem cells into mature beta cells expressing PDX1, NKX6.1, MAFA, UCN3 and SLC2A is considered.

EFFECT: this invention can be further used in cell substitution therapy for the treatment of diabetes mellitus.

43 cl, 10 dwg, 23 tbl, 7 ex

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RU 2 752 499 C2

Authors

Rieck, Sebastian

Rezania, Alireza

Dates

2021-07-28—Published

2017-06-14—Filed

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