SILICONE HYDROGEL CONTACT LENSES Russian patent published in 2022 - IPC G02B1/04 B29D11/00 

FIELD: medicine.

SUBSTANCE: invention relates to silicone hydrogel contact lenses. Technical result is achieved by a contact lens containing a silicone-hydrogel matrix material, which contains: (1) first repeating units of a siloxane-containing vinyl monomer, comprising from 0 to 10 first fragments, which are H-donors, (2) second repeating units of a polysiloxane-vinyl cross-linking agent with a linear elongated chain, which is characterized by a number average molecular weight of 3,000 to 80,000 Da and contains two terminal (meth)acryloyl groups and two polysiloxane segments, where each pair of adjacent polysiloxane segments is bonded by means of one divalent organic radical, containing one or more second fragments, which are H-donors, (3) third repeating units of hydrophilic N-vinylamide monomer and (4) optionally fourth repeating units of a polysiloxane-vinyl cross-linking agent containing from 0 to 35 third fragments, which are H-donors. Polysiloxane-vinyl cross-linking agent with linear elongated chain is different from polysiloxane-vinyl cross-linking agent, where the first, second and third fragments, which are H-donors, independently represent hydroxyl groups, carboxyl groups, amino groups of formula -NHR^o, amine bridges of formula -NH-, amide bridges of formula -CONH-, urethane bridges of formula -OCONH-, urea bonds of formula -HNCONH- or combinations thereof, where R^o is H or C₁-C₄ alkyl. Silicone hydrogel matrix material contains at least 8.8 mmole of third repeating units in terms of gram sum of all first, second and fourth repeating links and at least 0.11 meq sum of all first, second and third fragments representing H-donors in terms of gram of third repeating units. Silicone hydrogel contact lens is characterized by an oxygen permeability of at least 70 barrers, a modulus of elasticity of 0.2 to 1.5 MPa, and an equilibrium water content, making from 40 to 70 % by weight, and is naturally wettable, that is, is characterized by a water film rupture time of at least 10 seconds, and a water contact angle, by a certain “sticking bubble” method of 80 degrees or less, without any surface treatment after hardening.

EFFECT: relatively high oxygen permeability, relatively high water content, relatively low modulus and relatively low percentage of atomic Si on the surface of the contact lens.

28 cl, 1 dwg, 9 tbl, 38 ex