METHOD OF PRODUCING ISOTOPE Russian patent published in 2022 - IPC A61K51/00 C01F15/00 B01D15/04 B01J39/05 B01J41/05 

FIELD: chemical or physical processes.

SUBSTANCE: invention relates to production of thorium-227. Disclosed is a method of generating ²²⁷Th of pharmaceutically acceptable purity, comprising I) obtaining a mixture of generator comprising ²²⁷Ac, ²²⁷Th and ²²³Ra; II) loading said generator mixture onto a strongly basic anion-exchange resin; III) elution of a mixture of said ²²³Ra and ²²⁷Ac from said strongly basic anion-exchange resin using a first mineral acid in an aqueous solution; IV) elution of ²²⁷Th from said strongly basic anion-exchange resin using a second mineral acid in an aqueous solution, wherein first ²²⁷Th solution containing impurity of ²²³Ra and ²²⁷Ac is generated; V) loading first ²²⁷Th solution onto a strongly acidic cation-exchange resin; VI) elution of at least portion of ²²³Ra and ²²⁷Ac impurities from said strongly acidic cation-exchange resin using a third mineral acid in an aqueous solution; VII) elution of ²²⁷Th from said strongly acidic cation exchange resin using a first aqueous buffer solution to provide a second solution of ²²⁷Th; VIII) loading second ²²⁷Th solution eluted at step VII) onto a second strongly basic anion-exchange resin; IX) elution of ²²³Ra and/or ²²⁷Ac from said strongly basic anion-exchange resin using a fourth mineral acid in an aqueous solution; and X) elution of ²²⁷Th from said strongly basic anion-exchange resin using a fifth mineral acid in an aqueous solution to provide a third solution of ²²⁷Th.

EFFECT: invention enables to obtain thorium-227 of high radiochemical purity and loss of not more than 0,05 % of initial ²²⁷Ac during each regeneration cycle.

25 cl, 2 tbl, 2 ex, 1 dwg