SENSOR SYSTEMS Russian patent published in 2022 - IPC G01N33/543 

FIELD: sensors.

SUBSTANCE: group of inventions relates to the field of sensor systems for detecting molecules. Sensor system for detecting single molecules comprises a charge sensor including two electrodes; and a conductive channel connecting the two electrodes; a charged molecule attached to the conductive channel. The charged molecule includes a recognition site for reversibly binding the label of the labelled nucleotide; has an unbound preferred conformation associated with the unbound charge configuration; and has a preferred conformation associated with the charge configuration when the recognition site is associated with the label, wherein the charge configuration differs from the unbound charge configuration; and a polymerase attached to the conductive channel or the charged molecule. Also disclosed is a variant of the sensor system for detecting single molecules, variants of sensor apparatuses for detecting single molecules, and a method for detecting single molecules.

EFFECT: group of inventions provides sensor systems for detecting single molecules wherein a charged molecule can be subjected to reversible binding with a target label attached to a nucleotide.

23 cl, 7 dwg