SOLID-PHASE METHOD FOR PRODUCING A BIOLOGICALLY ACTIVE COMPOSITION BASED ON CHELATE COMPLEXES OF ZINC, MAGNESIUM, MANGANESE, COPPER, AND CHROMIUM WITH HYALURONIC ACID Russian patent published in 2022 - IPC C08B37/08 A61K31/728 

FIELD: chemistry.

SUBSTANCE: invention relates to a solid-phase method for producing biologically active compositions constituting chelate complexes of hyaluronic acid with essential trace elements: zinc, magnesium, manganese, copper, and chromium. Method consists in processing a powdered mixture of hyaluronic acid with a molecular weight of 15 to 50 kDa with a metal chloride in a dual-screw mechanochemical extruder with a feeding zone and two reaction zones at a zone length ratio of 20:40:40%, respectively, consecutively performing the following operations in a single processing cycle: loading the dry powder of hyaluronic acid and dry powder of metal chloride, wherein the metal is selected from the group of zinc, magnesium, manganese, copper, chromium, at a weight ratio of 1:0.015 to 0.035, respectively, to the feed zone of the mechanochemical extruder, and homogenising by stirring in said zone for 2 to 3 minutes at 5 to 10°C; further consecutively automatically moving the homogenised mixture to the second and third zones of the mechanochemical extruder, wherein the mechanochemical reaction is conducted while simultaneously subjecting the mixture to pressure from 200 to 300 MPa and to shear deformation on cam mechanisms with a total shear angle of 180° for 1 to 2 minutes in a nitrogen current at a temperature of 70 to 80°C in the second mechanochemical zone and 5 to 7°C in the third mechanochemical zone.

EFFECT: single-stage solid-phase method for producing chelate complexes of hyaluronic acid in the absence of a liquid without high energy, labour and water consumption, providing the possibility of creating target products with a high output, increased biological availability, and stability, potentially usable as a target additive in hydrogel compositions of hyaluronic acid.

1 cl, 2 dwg, 1 tbl, 10 ex