FIELD: medicine.
SUBSTANCE: invention relates to medicine and can be used to treat soft tissue tumors whose cells express HER2 by delivering therapeutic agents to the cells of the tumor node. A method for targeted delivery of therapeutic drugs to tumor cells by intratumoral administration of a composition of hydrogel and recombinant monoclonal antibodies to HER2, in which the specified composition is administered by intratumoral injection of an implant in the form of a scaffold, which is a tube made of titanium alloy VT6, 5-10 mm long, with a wall thickness of 1±0.02 mm, with an internal diameter of 2-4 mm, with a polished outer surface and edges, having a longitudinal hole on the side of a width of 1±0.05 mm, the inner cavity of which is filled with a composition of hydrogel and recombinant monoclonal antibodies to HER2 in a 1:1 ratio.
EFFECT: invention provides minimization of mechanical traumatization of surrounding tissues during scaffold implantation, prolonged release of the immunopreparation.
1 cl, 1 ex, 1 dwg
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