METHOD FOR DIFFERENTIAL DIAGNOSTICS OF DIABETES MELLITUS TYPE Russian patent published in 2023 - IPC G01N33/53 A61B5/145 

FIELD: clinical diagnostics.

SUBSTANCE: present invention relates to the field of clinical diagnostics, namely to a method for differential diagnostics of a diabetes mellitus type in pregnant women. The method includes taking a patient’s blood sample; sample preparation of the patient’s blood sample to obtain analyte; determination in analyte of a content, as markers of diabetes mellitus, of Protein AMBP, Inter-alpha-trypsin inhibitor heavy chain H2, Inter-alpha-trypsin inhibitor heavy chain H1, Kininogen-1, Apolipoprotein A-I, Apolipoprotein E proteins. If a value of the relative content of Protein AMBP is not less than 1.15% of the total protein content in analyte, in the absence of “obesity” diagnosis in a patient, and/or if a value of the relative content of Kininogen-1 is in the range of 0.44-0.58% of the total protein content in analyte, type I diabetes mellitus is detected. If the relative content of Kininogen-1 is in the range of 0.41-0.43% of the total protein content in analyte, type II diabetes mellitus is detected. If a value of the relative content of Protein AMBP is in the range of 0.77-0.90% of the total protein content in analyte, and/or if a value of the relative content of Inter-alpha-trypsin inhibitor heavy chain H2 is in the range of 0.29-0.31% of the total protein content in analyte, and/or if a value of the relative content of Inter-alpha-trypsin inhibitor heavy chain H1 is in the range of 0.26-0.28% of the total protein content in analyte, and/or if the relative content of Apolipoprotein A-I is in the range of 1.88-2.28% of the total protein content in analyte, and/ or if the relative content of Apolipoprotein E is not less than 0.61% and not more than 0.79% of the total protein content in analyte, gestational diabetes mellitus is detected.

EFFECT: invention provides an increase in the accuracy of analysis in diagnostics of diabetes mellitus in pregnant women, as well as expansion of the arsenal of existing methods for analysis in diagnostics of diabetes.

3 cl, 7 tbl, 3 ex