METHOD FOR EARLY DIAGNOSIS AND PREDICTION OF DIABETIC FETOPATHY IN GESTATIONAL DIABETES MELLITUS Russian patent published in 2024 - IPC C12Q1/68 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely obstetrics and perinatology, and can be used for prediction of early neonatal complications in newborns from mothers with gestational diabetes mellitus, particularly diabetic fetopathy. Disclosed is a method for diagnosing a high risk of developing diabetic fetopathy in gestational diabetes mellitus in full-term pregnancy, characterized by the fact that the presence of genetic markers is assessed, namely: C/T or T/T gene DRD-2 polymorphisms in serum of pregnant women with GDM, associated with high risk of diabetic fetopathy development, at that, genomic DNA is recovered from peripheral blood leukocytes by thermo-coagulation method, detection of amplification products is performed by method of horizontal electrophoresis in 2% agarose gel using DNA markers with molecular weight of 100–1,000 bp, SNP-genotyping of DRD-2/ANKK1 is carried out by TaqMan-PCR in real time using TaqMan-probes. If observing the carriage of the C/T or T/T variants, the patients are referred to a group of high risk of developing diabetic fetopathy.

EFFECT: method enables rational delivery, which reduces the frequency of unfavourable foetal outcomes from mothers with gestational diabetes mellitus.

1 cl, 3 ex