FIELD: nanomaterials.
SUBSTANCE: group of inventions relates to ultrastable gold nanoparticles containing carbene ligands, a method for their preparation, conjugates with biomolecules containing these nanoparticles, and also to the use of such nanoparticles. The invention relates to the field of nanomaterials, namely to a compound of general formula II, where R1 and R2 are independently selected from the group consisting of COOR5; R3 and R4 are independently selected from the group consisting of H; C1-C6 alkyl optionally substituted with one or more substituents selected from the group consisting of C1-C6 alkyl, C3-C7 cycloalkyl, C1-C6 alkyloxy and halogen; aryl optionally substituted with one or more substituents selected from the group consisting of C1-C6 alkyl, C3-C7 cycloalkyl, C1-C6 alkyloxy and halo; R 5 is selected from the group consisting of H; C1-C6 alkyl; C3-C7 cycloalkyl; C1-C6 alkyloxy and halogen; X is an anion selected from the group consisting of halide, nitrate, tosylate, triflate, acetate, hexachlorophosphate, tetrafluoroborate, and hexachloroplatinate; n takes a value from 3 to 12. Also the following are proposed: a gold nanoparticle obtained by the interaction of a compound of formula III and a base in a polar protic solvent by heating from 50 to 100°С from 2 to 8 hours, the conjugate with biomolecules formed by this nanoparticle, and the use of nanoparticles and conjugates in biology and medicine, in particular, as drug delivery vehicles, contrast agents and markers for immunochemical tests.
EFFECT: increasing the resistance of water-soluble gold nanoparticles to external physical and chemical influences, facilitating the storage and transportation of gold nanoparticles, enabling the use of gold nanoparticles in molecular express test systems without additional surfactants and stabilizers, as well as reducing the synthesis stages of gold nanoparticles.
18 cl, 18 dwg, 24 ex
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