FIELD: medicine.
SUBSTANCE: invention relates to the use of 2-substituted 5-(hetero)alkyl-6-hydroxypyrimidine-4(1H)-ones of the general formula
,
where R=i-Pr, CH3CH2CH2CH(CH3), CH3CH(CH3)CH2CH2, MeSCH2CH2, R1=SCH2CH2N(CH3)2, SCH2CH2N(CH3CH2)2, SCH2CH2N(CH2)4, SCH2CH2N(CH2)5, SCH2CH2SCH3, thiomorpholine-4-yl, or their hydrochloric acid salts as active principles of drugs having antidepressant properties.
EFFECT: expansion of the range of compounds having an antidepressant effect.
1 cl, 2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| 2-SUBSTITUTED 5-(HETERO)ALKYL-6-HYDROXYPYRIMIDINE-4(1H)-ONES WITH ANXIOLYTIC ACTIVITY | 2021 |
|
RU2793570C1 |
| 2-SUBSTITUTED 5-(HETERO)ALKYL-6-HYDROXYPYRIMIDINE-4(1H)-ONES WITH NOOTROPIC ACTIVITY | 2022 |
|
RU2793806C1 |
| METHOD FOR MAKING 2-AMINO-4-ARYL-6-HEXYL-7-HYDROXY-4H-CHROMEN-3-CARBONITRILES | 2022 |
|
RU2802631C1 |
| METHOD FOR PRODUCING ISOTHIOBARBAMINE | 2020 |
|
RU2744470C1 |
| METHOD OF PRODUCING 4-ARYL-SUBSTITUTED 7-HYDROXY-6'-PHENYL-5',6'-DIHYDRO-1'H-SPIRO[CHROMAN-2,4'-PYRIMIDINE]-2'(3'H)-ONES | 2023 |
|
RU2818006C1 |
| METHOD OF PRODUCING 4-ARYL-SUBSTITUTED 8-HYDROXY-5,10A-DIMETHYL-1,3,4,10A-TETRAHYDRO-2H-CHROMENO[2,3-D]PYRIMIDIN-2-ONES(THIONS) | 2023 |
|
RU2821110C1 |
| METHOD FOR PREPARING SUBSTITUTED O-ALKYLATED HEXAHYDRO-2H-CHROMENO[4,3-D]PYRIMIDINE-2,5(1H)-DIONES | 2022 |
|
RU2796532C1 |
| 2-(CHROMENO[4,3-D]PYRIMIDIN-5-YL)ACETIC ACID DERIVATIVES AND A METHOD FOR PRODUCTION THEREOF | 2019 |
|
RU2716597C1 |
| DERIVATIVES OF 2-(PYRANO[3,2-C]CHROMEN-5-YL)ACETIC ACID AND METHOD FOR THEIR PREPARATION | 2021 |
|
RU2775546C1 |
| METHOD FOR SYNTHESIS OF 1-(2-AMINO-4-NITROPHENYL)-2-R-BENZIMIDAZOLES | 2024 |
|
RU2825732C1 |
