METHOD FOR DIAGNOSING DISORDERS OF THE FUNCTIONAL STATE OF THE THYROID GLAND IN CHILDREN 4-10 YEARS OLD LIVING IN THE FAR NORTH Russian patent published in 2023 - IPC G01N33/58 C12Q1/6806 C12Q1/6827 C12Q1/686 C12Q1/6876 

FIELD: medicine.

SUBSTANCE: invention relates to medical genetics, pediatrics, pediatric endocrinology, and can be used for diagnosing disorders of the functional state of the thyroid gland in children 4–10 years old living in the Far North. A urine sample and a sample of the buccal epithelium are taken from the child. The iodine content is determined in the urine sample. DNA is isolated from the buccal epithelium. Using a polymerase chain reaction, the genotyping of the polymorphism of the organic anion carrier protein gene 1B1 OATP1B1 (rs2306283) is carried out on a detecting amplifier using primers. In the presence of a variant homozygous genotype of the rs2306283 polymorphism and a decrease in the level of iodine in the urine by more than 1.5 times compared with the lower limit of the physiological norm, equal to 10.0 μg/100 cm³, a violation of the functional state of the thyroid gland in children 4–10 years old living in the Far North is diagnosed.

EFFECT: method enables reliable detection of thyroid disease in children 4–10 years old living in the Far North by determining the presence of a variant homozygous genotype of the rs2306283 polymorphism and reducing the iodine content in the urine.

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