METHOD FOR DIAGNOSING OXIDATIVE STRESS IN CASE OF MISCARRIAGE Russian patent published in 2023 - IPC G01N33/573 G01N33/68 G01N33/92 

FIELD: medicine; obstetrics; clinical laboratory diagnostics.

SUBSTANCE: invention can be used to diagnose oxidative stress in case of miscarriage by biochemical study of biomaterial. In chorion tissues obtained as a result of spontaneous abortion or by instrumental curettage of the uterine cavity, the level of malondialdehyde is determined during spontaneous, enzymatic and non-enzymatic reactions of lipid peroxidation, the indicator of superoxide dismutase activity and the level of growth and differentiation factor-15 are also determined. At values of the level of malondialdehyde during a spontaneous lipid peroxidation reaction of at least 7.75 nmol/h, with an enzymatic lipid peroxidation reaction of at least 6.46 nmol/h, with a non-enzymatic lipid peroxidation reaction of at least 16.61 nmol/h, indicator of activity of superoxide dimutase is not less than 245.8 ng/ml, the level of growth and differentiation factor-15 is not more than 3,259 pg/ml, oxidative stress is diagnosed in case of miscarriage.

EFFECT: method provides the possibility of increasing the reliability and information content of diagnosing the pathogenetic mechanisms of miscarriage by determining the level of malondialdehyde in chorion tissues, the indicator of superoxide dismutase activity and the level of growth and differentiation factor-15, which makes it possible to identify the mechanism of oxidative stress.

1 cl, 4 ex