METHOD OF DIAGNOSING PROTEOLYTIC DISORDERS IN MISCARRIAGE Russian patent published in 2024 - IPC G01N33/68 G01N33/573 

FIELD: medicine; gynecology.

SUBSTANCE: invention can be used to diagnose proteolytic disorders during miscarriage by enzyme immunoassay of chorion tissue. In chorion tissues obtained as a result of spontaneous abortion or by instrumental curettage of the uterine cavity, the level of leukocyte elastase, alpha 2 — macroglobulin and secretory inhibitor of leukocyte proteinase are simultaneously determined. When the level of elastase is more than 64 ng/ml, the level of alpha 2 — macroglobulin is more than 7.08 ng/ml and the level of secretory inhibitor of leukocyte proteinase is not more than 81.2 pg/ml, proteolytic disorders are diagnosed in case of miscarriage.

EFFECT: method provides the opportunity to increase the reliability and information content of the diagnosis of pathogenetic mechanisms of miscarriage by determining the level of leukocyte elastase, alpha 2 — macroglobulin and secretory inhibitor of leukocyte proteinase in chorion tissues.

1 cl, 4 ex