FIELD: biochemistry.
SUBSTANCE: invention relates to an antibody which specifically binds IL-8. Also disclosed is an isolated nucleic acid encoding said antibody, an expression vector comprising said nucleic acid, a host cell comprising said vector, a pharmaceutical composition, containing said antibody is also disclosed. Disclosed is a method of producing said antibody, a method of treating a patient, a method of inhibiting angiogenesis and a method of inhibiting neutrophil migration, using said antibody, use of said antibody for preparing a pharmaceutical composition.
EFFECT: invention provides effective treatment of disorders characterized by IL-8 excess.
15 cl, 40 dwg, 42 tbl, 23 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF CHANGING PLASMA RETENTION AND IMMUNOGENICITY OF ANTIGEN-BINDING MOLECULES | 2012 |
|
RU2799423C1 |
| ANTIGEN-BINDING MOLECULE CAPABLE OF REPEATEDLY BINDING TWO OR MORE ANTIGEN MOLECULES | 2009 |
|
RU2571225C2 |
| ANTIGEN-BINDING MOLECULE, THAT IS CAPABLE OF MULTIPLE BINDING WITH A LOT OF ANTIGENIC MOLECULES | 2011 |
|
RU2658504C9 |
| LIBRARY OF CONCENTRATION-DEPENDENT ION BINDING MOLECULES | 2012 |
|
RU2812861C1 |
| Fc-REGION OPTION | 2014 |
|
RU2757124C2 |
| ANTIGEN-BINDING MOLECULE FOR ACCELERATING ANTIGEN LOSS | 2012 |
|
RU2772771C1 |
| ANTIGEN-BINDING MOLECULE, ABLE TO MULTIPLELY CONTACT WITH PLURALITY OF ANTIGENIC MOLECULES | 2011 |
|
RU2642318C2 |
| METHOD OF MODIFICATION OF POLYPEPTIDE FOR PURIFICATION OF POLYPEPTIDE MULTIMERS | 2010 |
|
RU2606264C2 |
| ANTIGEN-BINDING MOLECULE TO ACCELERATE ANTIGEN DISAPPEARANCE THROUGH FcγRIIB | 2013 |
|
RU2812226C1 |
| COMPOSITION FOR PREVENTION OR TREATMENT OF IL-8-RELATED DISEASES | 2017 |
|
RU2766112C2 |
