HETEROAROMATIC NMDA RECEPTOR MODULATORS AND THEIR USE Russian patent published in 2023 - IPC C07D487/04 A61K31/519 A61P25/18 A61P25/28 

Abstract RU 2800064 C2

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to 5-(3-chloro-4-fluorophenyl)-7-cyclopropyl-3-(2-(3-fluoro-3-methylazetidin-1-yl)-2-oxoethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one formula

and pharmaceutically acceptable salt thereof. Also a pharmaceutical composition containing the said compound or a pharmaceutically acceptable salt thereof are provided.

EFFECT: proposed compound is capable of modulating the activity of NMDA receptors and can be used in the treatment of psychiatric, neurological and neurodevelopmental disorders, as well as nervous system diseases.

12 cl, 2 dwg, 4 tbl, 2 ex

Similar patents RU2800064C2

Title Year Author Number
3,3-DIFLUOROPIPERIDINE CARBAMATE HETEROCYCLIC COMPOUNDS AS NR2B NMDA RECEPTOR ANTAGONISTS 2016
  • Shapiro, Gideon
RU2735277C2
PYRIDOPYRIMIDINONES AND USE THEREOF AS MODULATORS OF N-METHYL-D-ASPARTATE RECEPTOR 2016
  • Volgraf Metyu
  • Tszyan Yu
  • Villemur Eliziya
  • Sellers Bendzhamin
  • U Goshen
  • Lu Ajtszyun
RU2717665C2
SUBSTITUTED DIHYDRO BENZOCYCLOALKYLOXYMETHYL OXAZOLOPYRIMIDINONE, PREPARING AND USING THEM 2010
  • Kosli Rehjmond Uolter Ml.
  • Sher Rouzi
RU2543384C2
CYCLOPROPYLPIPERIDINE GLYCINE TRANSPORTER INHIBITORS 2005
  • Lindsli Krejg U.
  • Uisnoski Dehvid D.
  • Uolkenberg Skott Eh.
RU2387644C2
AMIDE DERIVATIVES OF CARBOXYLIC ACID, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF 2001
  • Khorvat Chilla
  • Farkash Shandor
  • Doman' D'Erd'
  • Borza Ishtvan
  • Bartane Chalai Gizela
  • Nad' Jozef
  • Kolok Shandor
RU2271361C2
COMPOUNDS AND METHODS 2015
  • Li, Peng
  • Zheng, Hailin
  • Zhao, Jun
  • Wennogle, Lawrence
RU2711442C2
POSITIVE ALLOSTERIC MODULATORS OF MUSCARINIC ACETYLCHOLINE RECEPTOR M4 2017
  • Lindsli, Krejg V.
  • Konn, P. Dzheffri
  • Engers, Darren V.
  • Bollinger, Shon
  • Tarr, Dzhejms S.
  • Spiaring, Pol
  • Engers, Dzhuli L.
  • Long, Madelin
  • Bridzhes, Tomas M.
RU2750935C2
3-FLUOROPIPERIDINES AS NMDA/NR2B ANTAGONISTS 2004
  • Liverton Najdzhel Dzh.
  • Klehjborn Kristofer F.
  • Klehjrmon Dehvid A.
  • Makkoli Dzhon A.
RU2339630C2
ORGANIC COMPOUNDS 2017
  • Yao, Wei
  • Li, Peng
RU2733975C2
PYRROLOPYRIMIDINE COMPOUNDS AND APPLICATION THEREOF 2011
  • Su Vehj-Go
  • Dehn Vehj
  • Li Tszin'Shuj
  • Tszi Tszjan'Go
RU2563644C2

RU 2 800 064 C2

Authors

Folkmann, Robert, A.

Anderson, Devid, R.

Malekiani, Sem

Pajzer, Timoti

Kini, Gregg, F.

Lejzer, Stiven, K.

Dates

2023-07-17Published

2019-08-02Filed