FIELD: molecular biotechnology and medicine.
SUBSTANCE: invention includes a genetic construct representing a linearized vector for obtaining transgenic mice with inducible systemic and tissue-specific expression of human cyclophilin A and a method of obtaining the said vector, as well as a line of transgenic mice expressing human cyclophilin A, and the method to obtain it.
EFFECT: invention provides obtaining a line of transgenic mice with inducible systemic and tissue-specific expression of human cyclophilin A, which can be used as models for a number of human inflammatory diseases, as well as to search for therapeutic approaches to treatment and to conduct preclinical trials.
4 cl, 5 dwg, 3 ex
Title | Year | Author | Number |
---|---|---|---|
METHOD FOR PRODUCING GENETICALLY MODIFIED LABORATORY ANIMALS WITH NULL ALLELE OF P2rx3 GENE | 2022 |
|
RU2805173C1 |
METHOD OF PRODUCING GENETICALLY MODIFIED MICE EXPRESSING HUMAN ANTITHROMBIN III MINIGENE USING MICROINJECTIONS OF TELN-LINEARIZED DNA FRAGMENT | 2022 |
|
RU2806568C1 |
METHOD OF PRODUCING MOUSE MODEL FOR STUDYING DUCHENNE MUSCULAR DYSTROPHY AND VERSIONS OF ITS THERAPY | 2023 |
|
RU2815936C1 |
MUS MUSCULUS 5B9 HYBRID CULTIVATED ANIMAL CELLS- A PRODUCER OF MOUSE MONOCLONAL ANTIBODY 5B9, MONOCLONAL MOUSE ANTIBODY 5B9 AND RECOMBINANT CHIMERIC (MOUSE-HUMAN) ANTIBODY XI5B9, NEUTRALIZING RICIN RICINUS COMMUNIS | 2022 |
|
RU2802436C1 |
BISPECIFIC ANTIBODIES AND THEIR APPLICATIONS | 2022 |
|
RU2821577C2 |
T7 PHAGE DNA-DEPENDENT RNA-POLYMERASE ENZYME PRODUCER STRAIN | 2022 |
|
RU2825469C2 |
RECOMBINANT STRAIN OF HERPESVIRUS SAIMIRI FOR OBTAINING POPULATIONS OF IMMORTALISED AUTOLOGOUS T LYMPHOCYTES EXPRESSING PAIRED CHIMERIC RECEPTORS AGAINST CD44 AND CD133 TUMOUR ANTIGENS | 2020 |
|
RU2771081C2 |
SET OF OLIGONUCLEOTIDE PRIMERS AND PROBES FOR IDENTIFYING HERPESVIRUS SAIMIRI IN CELL CULTURES BY MEANS OF PCR IN REAL TIME | 2020 |
|
RU2753767C1 |
ISOLATED MODIFIED CAPSID PROTEIN VPI OF ADENO-ASSOCIATED VIRUS SEROTYPE 5 (AAV5), CAPSID AND VECTOR BASED THEREON | 2021 |
|
RU2820088C1 |
NUCLEIC ACID FOR ALLOTOPIC EXPRESSION OF MT-ND4 GENE | 2023 |
|
RU2809065C1 |
Authors
Dates
2023-07-19—Published
2022-12-08—Filed