METHOD OF PREDICTING THE RISK OF FETAL GROWTH RESTRICTION IN THE FIRST HALF OF PREGNANCY Russian patent published in 2023 - IPC A61B8/06 G01N33/49 

FIELD: medicine; obstetrics; perinatology.

SUBSTANCE: invention can be used to predict the risk of fetal growth restriction in the first half of pregnancy. The method includes calculating a prognostic index (PI). The following gravidar factors are determined: threat of miscarriage (F1), centile values of the pulsatility index of the fetal ductus venosus at 11–13.6 weeks (F2), centile values of the pulsatility index of the fetal ductus venosus at 18–20.6 weeks (F3), level of β-hCG (F4), PAPP-A level (F5), centile indicators of the average values of the pulsatility index of the uterine arteries at 11–13.6 weeks (F6), centile indicators of the average values of the pulsatility index of the uterine arteries at 18–20.6 weeks (F7) and the presence of intrauterine infection (F8) and they are evaluated on a 3-point ranking scale; for values equal to zero, it is considered that the factor being studied is completely absent. Factors F1 and F8 are assessed as equal to 3 points or equal to 0 points; for factors F4 and F5, values of more than 1.5 MoM and less than 0.5 MoM are regarded as 3 points, values of 1.0–1.5 MoM — as 0 points, and values of 0.6–0.9 MoM — as 2 points; for factors F2, F3, F6, F7, values greater than the 95th percentile value are regarded as 3 points, less than the 10th percentile value are regarded as 2 points. The forecast coefficient for F1 is 0.109; for F2 is 0.076; for F3 is 0.052; for F4 is 0.036; for F5 is 0.024; for F6 is 0.017; for F7 is 0.011; for F8 is 0.008. PI is calculated using the following formula PI=(0.109×F1+0.076×F2+0.052×F3+0.036×F4+0.024×F5+0.017×F6+0.011×F7+0.008×F8)×100%; if the PI value is equal to or exceeds 45%, the risk of developing fetal growth restriction is assessed as high; if the PI value is less than 45%, the risk of developing fetal growth restriction is assessed as low.

EFFECT: method improves the accuracy of forecasting the development of fetal growth restriction (FGR) by calculating PI.

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