FIELD: medical equipment.
SUBSTANCE: device for inhalation of dry powder, a cartridge for dry powder, a method for delivering dry powder to a subject and a kit for delivering dry powder. The dry powder inhalation device includes a cartridge having a proximal end, a distal end and an outer part with grooves. The cartridge is configured to hold dry powder. The device has an activation button attached to the distal end of the cartridge. The device includes a delivery chamber containing a through lumen, a proximal end and a distal end. The distal end of the delivery chamber is adjacent to the proximal end of the cartridge. The device has a mouthpiece adjacent to the proximal end of the delivery chamber. The mouthpiece contains a lumen in fluid communication with the lumen of the delivery chamber. The device includes a vortex element located between the mouthpiece and the delivery chamber. The device contains an elongated body containing a lumen that accommodates a cartridge, a delivery chamber, a vortex element and a mouthpiece. When the activation button is activated, dry powder is placed from the cartridge into the lumen of the delivery chamber. The device is designed in such a way that during use, air is drawn along the cartridge, deflected through the grooved outer portion and enters the delivery chamber, moving turbulently to capture the dry powder, then passes through the vortex element with increasing turbulence to be drawn through the lumen of the mouthpiece. The dry powder cartridge includes a cylindrical main body containing a lumen having a proximal opening at a proximal end, and a distal opening at the distal end, and a longitudinal axis passing through it, and an outer part with grooves. The cartridge includes a reservoir at the proximal end of the cylindrical main body in fluid communication with the lumen. The cartridge has a movable shaft having a proximal end and a distal end and located in the lumen and reservoir of the main part. The distal end of the movable shaft protrudes from the distal hole of the cylindrical main part, the shaft is configured to move along the longitudinal axis of the cylindrical main part. The movable shaft includes a groove at its proximal end and a locking flange in the center of the movable shaft. The groove is configured to slide away from the reservoir through the proximal opening of the main part. The cartridge has a first cartridge seal and a second cartridge seal configured to seal the space between the proximal opening of the cylindrical body and the movable shaft passing therethrough. The cartridge includes a third cartridge seal configured to seal the space between the distal opening of the cylindrical main body and the movable shaft passing therethrough. The second cartridge seal and the third cartridge seal are configured to limit proximal and distal movement of the movable shaft, respectively, by blocking the locking flange. The method includes the following stages: providing a dry powder inhalation device comprising a cartridge containing dry powder and having a grooved outer part, an activation button, a delivery chamber, a mouthpiece, and an elongated body enclosing the cartridge, a delivery chamber, and a mouthpiece; press the activation button to place the dry powder from the cartridge into the delivery chamber; and apply vacuum to the mouthpiece. In the method, a vacuum draws air along the cartridge and the air is deflected by a grooved outer surface to enter a delivery chamber, moving turbulently to entrain dry powder into the air, and the vacuum draws air with entrained dry powder through a mouthpiece and into the subject's body. The kit contains a dry powder inhalation device.
EFFECT: providing a dry powder inhaler that creates sufficient turbulence within the dry powder chamber to allow increased amounts of powder to be moved into the air for inhalation by the user, while maintaining ease of use in a discrete design.
19 cl, 13 dwg
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Authors
Dates
2023-10-18—Published
2020-01-13—Filed