DEUTERATED ANALOGUES OF ACETYLEUCINE Russian patent published in 2023 - IPC C07C233/47 C07B59/00 A61K31/198 A61P25/06 A61P25/28 

FIELD: pharmaceuticals.

SUBSTANCE: invention provides a compound or a pharmaceutically acceptable salt or solvate thereof selected from the group consisting of the following:

Also the following is provided: pharmaceutical compositions and kits containing a compound of formula I

or a pharmaceutically acceptable salt or solvate thereof, wherein R¹, R², R³, R⁴, R⁵, R⁶, R⁷, R⁸, R⁹, R¹⁰, R¹¹, R¹² and R¹³ are as follows: specified in the claims, and the degree of deuterium enrichment of any one or more of R³, R⁴, R⁵, R⁶, R⁷, R⁸, R⁹, R¹⁰, R¹¹, R¹² and R¹³ is about 15% or more.

EFFECT: compounds of the invention are useful in treating or slowing the progression of a lysosomal storage disease or neurodegenerative disease in a subject, providing neuroprotection in a subject having a lysosomal disease.

27 cl, 6 dwg, 12 ex