PREVENTIVE OR THERAPEUTIC REMEDY FOR PHOTODERMATOSIS Russian patent published in 2024 - IPC A61K31/454 A61P17/00 A61P37/08 

FIELD: pharmaceutical chemistry.

SUBSTANCE: group of inventions includes the use of a cocrystal of 1-{2-[(3S,4R)-1-{[(3R,4R)-1-cyclopentyl-3-fluoro-4-(4-methoxyphenyl)pyrrolidine-3-yl]carbonyl}-4-(methoxymethyl)pyrrolidin-3-yl]-5-(trifluoromethyl)phenyl}piperidine-4-carboxylic acid with phosphoric acid in the manufacture of a medicinal product for the treatment or prevention of conditions other than protoporphyria and generalized vitiligo, which is treatable or preventable as a result of stimulation of melanin production, as well as a method of treatment and use of the specified co-crystal for the treatment or prevention of a condition, excluding protoporphyria and generalized vitiligo, which is treatable or preventable as a result of stimulation of melanin production. Where the amount of cocrystal administered is from 50 to 600 mg/day based on the amount of 1-{2-[(3S,4R)-1-{[(3R,4R)-1-cyclopentyl-3-fluoro-4-(4 -methoxyphenyl)pyrrolidin-3-yl]carbonyl}-4-(methoxymethyl)pyrrolidin-3-yl]-5-(trifluoromethyl)phenyl}piperidine-4-carboxylic acid.

EFFECT: treatment or prevention conditions resulting from stimulation of melanin production with the exception of protoporphyria and generalized vitiligo.

11 cl, 4 dwg, 6 tbl, 7 ex