METHOD OF PREDICTING DISEASE PROGRESSION OVER NEXT THREE MONTHS IN CANCER PATIENTS WITH SOLID TUMORS Russian patent published in 2024 - IPC G01N33/48 G01N33/574 G06N3/04 

FIELD: medicine; immunology; oncology.

SUBSTANCE: invention can be used to predict disease progression over the next three months in cancer patients with solid tumours. The following clinical and immunological parameters of the patient are determined: gender, age of the patient, oncological diagnosis, stage of the disease, prognostic group of the disease, duration of treatment, duration of the disease, type of treatment at the current stage and type of previous treatment, content of T- and B-lymphocytes, natural killer cells, cytotoxic lymphocytes, T-helper cells, and the value of the immunoregulatory index. The obtained information is transferred to the algorithm for constructing an ensemble of decision trees. During the operation of the ensemble of decision trees, the result of an integral assessment of the probability of process progression is obtained. If the probability is greater than or equal to 0.3812, a high probability of disease progression over the next three months is predicted.

EFFECT: method provides an objective assessment of the criteria for stopping, resuming and changing therapy for cancer patients with solid tumours based on the analysis of clinical and immunological factors using a predictive algorithm for constructing an ensemble of decision trees based on gradient boosting.

1 cl, 3 dwg, 4 tbl, 3 ex