MODULATION OF POLYMER GRANULES FOR DNA PROCESSING Russian patent published in 2024 - IPC C08K7/16 C12Q1/6806 

FIELD: chemistry.

SUBSTANCE: group of inventions relates to a polymer granule for conducting a plurality of combined analysis reactions, comprising: a hydrogel polymer precursor; cross-linking agent; and a biomolecule within the polymer granule, wherein the granule is a porous hollow granule, wherein the granule comprises a plurality of polymer layers, wherein each layer is characterized by a certain pore size and pore density, providing diffusion of the reagent through the granule, which retains the biomolecule, also relates to a method for conducting a plurality of successive joint analyses of a biomolecule encapsulated inside a polymer granule, involving: obtaining a polymer granule encapsulating a biomolecule; and sequential bringing a single cell into contact with reagents for multiple sequential combined assays.

EFFECT: group of inventions provides a polymer granule for fast and effective treatment by reducing the loss of biomolecules by retaining them inside the granule, while providing diffusion of one or more reagents through the granule.

32 cl, 29 dwg, 7 ex