METHOD OF PRODUCING NANOPARTICLES OF BISMUTH WITH TRIGGER PH-DEPENDENT TRANSFORMATION FOR BIOMEDICAL APPLICATIONS Russian patent published in 2024 - IPC A61K33/245 C01G29/00 B22F9/14 A61K47/56 A61K9/14 A61P35/00 B82B3/00 B82Y30/00 B82Y40/00 B82Y5/00 C22B30/06 B01J13/00 

FIELD: nanotechnology.

SUBSTANCE: invention can be used to produce bismuth nanoparticles which can be used as drug carriers for their trigger delivery into cancer cells. Method of producing bismuth nanoparticles with trigger pH-dependent transformation involves irradiating the surface of a bismuth target immersed in acetone or isopropanol with laser pulses for at least 1 min to obtain a colloidal solution. Pulse repetition frequency is from 100 Hz to 100 MHz, energy in pulse is from 5 to 400 mcJ. Obtained colloidal solution is centrifuged at 5,000 to 15,000 g for 30 s to 3 minutes to obtain a supernatant with bismuth nanoparticles. Obtained bismuth nanoparticles are coated with biocompatible polymer, adding at least 60 wt.% of powder of biocompatible polymer Pluronic F127 to the obtained supernatant liquid and stirring the obtained solution for at least 5 minutes. Coated bismuth nanoparticles are washed from excess biocompatible polymer by centrifuging the solution with acceleration of at least 3,000 g for at least 10 minutes.

EFFECT: invention enables to obtain bismuth nanoparticles, the morphological and optical properties of which can change under conditions of low pH of the medium, which is characteristic of cancer cells.

1 cl, 3 dwg, 3 ex