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IPC

C12Q1/6806(2018-01-01)

C12Q1/6827(2018-01-01)

C12Q1/686(2018-01-01)

(21) (22)

Application

2024116012, 2024-06-11

(24)

Start date

2024-06-11

(22)

Actual filing date

2024-06-11

(45)

Published

2024-08-26

(72)

Inventor

Bushueva Olga IurevnaAndrosova Elena AleksandrovnaKudriavtseva Olga KonstantinovnaBrezhnev Andrei IurevichMedvedeva Marina ViktorovnaPolonikov Aleksei Valerevich

(73)

Holder

Federalnoe Gosudarstvennoe Biudzhetnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniia Gosudarstvennyi Meditsinskii Universitet" Ministerstva Zdravookhraneniia Rossiiskoi Federatsii

METHOD FOR GENOTYPING POLYMORPHIC LOCUS rs648595 (T>G) OF GCLC GENE IN HUMAN BY REAL-TIME PCR USING ALLELE-SPECIFIC FLUORESCENT PROBES Russian patent published in 2024 - IPC C12Q1/6806 C12Q1/6827 C12Q1/686

Abstract RU 2825464 C1

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology, particularly to a method for genotyping a polymorphic locus rs648595 (T>G) of the GCLC gene in humans. Said method is carried out by real-time PCR. Identification of allelic variants of rs7907606 (T>G) is carried out using forward and reverse primers rs648595, characterized by sequences SEQ ID NO: 1 and SEQ ID NO: 2, as well as rs648595-T-allele-specific and rs648595-G-allele-specific fluorescent-labelled probes, characterized by sequences of SEQ ID NO: 3 and SEQ ID NO: 4.

EFFECT: invention provides an easy-to-implement and cost-effective method of genotyping a single-nucleotide polymorphism rs648595 (T>G) localized in a position chr6:53513571 (GRCh38_p14) of the GCLC gene.

1 cl, 1 dwg

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RU 2 825 464 C1

Authors

Bushueva Olga Iurevna

Androsova Elena Aleksandrovna

Kudriavtseva Olga Konstantinovna

Brezhnev Andrei Iurevich

Medvedeva Marina Viktorovna

Polonikov Aleksei Valerevich

Dates

2024-08-26—Published

2024-06-11—Filed