METHOD FOR DETERMINING NEED FOR ASSISTED REPRODUCTIVE TECHNOLOGIES (ART) WITH SPERM DONATION IN OBSTRUCTIVE MALE INFERTILITY Russian patent published in 2024 - IPC G01N33/48 G01N1/28 

Abstract RU 2830702 C1

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to urology, andrology, reproductology, clinical laboratory diagnostics, and can be used to determine the need for assisted reproductive technology (ART) programs with sperm donation in males with obstructive azoospermia. For this purpose, testicular biopsy material is obtained in males with reproductive tract obstruction. Then, spermatogenesis state is examined by light microscopy on a histological section of cross sections of convoluted seminiferous tubules on a ten-point scale. Further, testicular interstitium and presence of tryptase-positive mast cells in 1 mm2, which are contrasted by means of immunohistochemical staining, are examined. If the value of tryptase-positive mast cells is 23 and more in 1 mm2 in the interstitium of the testicle with underlying spermatogenesis disorder of 6 points and below, the need to perform a protocol of assisted reproductive technologies with sperm donation is determined.

EFFECT: invention enables to determine the success of ART programs in obstructive azoospermia, thus to take timely measures for implementation of repeated protocol of assisted reproductive technologies using autospermia or donation of germ cells, thereby reducing the number of unsuccessful attempts of ART.

1 cl, 3 ex

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RU 2 830 702 C1

Authors

Kulchenko Nina Gennadevna

Faniev Mikhail Vladimirovich

Atiakshin Dmitrii Andreevich

Kadyrov Zieratsho Abdulloevich

Gushchina Iuliia Shamilevna

Dates

2024-11-26Published

2024-05-22Filed