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2 833 143

(13)

C1

(51)

IPC

A61B17/00(2006-01-01)

A61M25/01(2006-01-01)

A61K31/505(2006-01-01)

A61K35/13(2015-01-01)

A61P43/00(2006-01-01)

G09B23/28(2006-01-01)

(21) (22)

Application

2024121299, 2024-07-26

(24)

Start date

2024-07-26

(22)

Actual filing date

2024-07-26

(45)

Published

2025-01-14

(72)

Inventor

Frantsiiants Elena MikhailovnaShikhliarova Alla IvanovnaKaplieva Irina ViktorovnaBandovkina Valeriia AkhtiamovnaPogorelova Iuliia AleksandrovnaNeskubina Irina ValerevnaTrepitaki Lidiia KonstantinovnaSurikova Ekaterina IgorevnaCheriarina Natalia DmitrievnaKotieva Violetta MikhailovnaVereskunova Aleksandra AlekseevnaCherkasova Anna AnatolevnaZhenilo Oksana EvgenevnaIshonina Oksana Georgievna

(73)

Holder

Federalnoe Gosudarstvennoe Biudzhetnoe Uchrezhdenie Meditsinskii Issledovatelskii Tsentr Onkologii" Ministerstva Zdravookhraneniia Rossiiskoi Federatsii

METHOD FOR MODELLING GUERIN CARCINOMA IN UTERUS WITH UNDERLYING DIABETES MELLITUS Russian patent published in 2025 - IPC A61B17/00 A61M25/01 A61K31/505 A61K35/13 A61P43/00 G09B23/28 

Abstract RU 2833143 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to oncology. Alloxan is injected intraperitoneally in female white outbred rats in dose of 15 mg/100 g of body weight. After 24 hours, the animals into the lumen of the right uterine horn using an intravenous catheter with an injection port of 22G, 0.9×25 mm, 0.5 ml of a tumour suspension of Guerin carcinoma is introduced in amount of (2.5-3.5)×106 cells. After insertion, the uterine horn is ligatured.

EFFECT: method enables to reproduce the Guerin carcinoma model developing with underlying diabetes mellitus, which in turn makes it possible to study the pathogenesis of the malignant process and the effect of the comorbid pathology on it, as well as to search for targets for the targeted therapy.

1 cl, 1 ex, 4 dwg

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RU 2 833 143 C1

Authors

Frantsiiants Elena Mikhailovna

Shikhliarova Alla Ivanovna

Kaplieva Irina Viktorovna

Bandovkina Valeriia Akhtiamovna

Pogorelova Iuliia Aleksandrovna

Neskubina Irina Valerevna

Trepitaki Lidiia Konstantinovna

Surikova Ekaterina Igorevna

Cheriarina Natalia Dmitrievna

Kotieva Violetta Mikhailovna

Vereskunova Aleksandra Alekseevna

Cherkasova Anna Anatolevna

Zhenilo Oksana Evgenevna

Ishonina Oksana Georgievna

Dates

2025-01-14—Published

2024-07-26—Filed

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