DERIVATIVES OF ALKENYLBENZOYLGUANIDINE, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel derivatives of alkenylbenzoylguanidine of the formula (I) where R¹ and R² each independently each of other means H, A, NO₂,SO_n-R⁴; R³ means or C_3-7-cycloalkenyl, or C_4-8-cycloalke- -nylalkyl; R⁴ means A; R⁵-R¹¹ each independently each of other means H or A; A is C_1-6-alkyl; N =1 or 2, and their physiologicaly tolerantable salts show ability to inhibit cellular Na⁺/H⁺-exchange and can be used as cardioprotective agents for treatment of patients with diseases caused by Na⁺/H⁺-exchange disorder. Invention describes also method of synthesis of compounds of the formula (I). EFFECT: new compounds indicated above, improved method of synthesis, valuable medicinal properties. 7 cl, 1 tbl, 12 ex