HETEROCYCLYL-BENZOYLGUANIDINES, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION Russian patent published in 2000 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to heterocyclyl-benzoylguanidines of the formula (I) where R¹ is A, CF₃, CH₂F,, Hal; X is R⁴; R² is SO₂-A; R³ is H; R⁴ is H or A; Het is saturated or unsaturated aromatic mono- or dinucleus aromatic heterocycle with 1-2 atoms of nitrogen or with oxygen atom bound through nitrogen or carbon atom and possibly substituted with alkyl, amino-group or hydroxyl-group; A is alkyl; X is O; Hal is F, Cl, Br, J and their physiologically acceptable salts. Compounds are inhibitors of Na⁺/H⁺-pump and show good antiarrhythmic activity. EFFECT: improved method of synthesis, valuable medicinal properties. 6 cl