DERIVATIVES OF BENZOYLGUANIDINE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION, METHOD OF ITS PREPARING Russian patent published in 2000 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes the novel derivatives of benzoylguanidine of the general formula (I) where R¹ is methyl or ethyl; R² is hydrogen atom, direct or branched C₁-C₆-alkyl, C₃-C₇-cycloalkyl, benzyl, unsubstituted phenyl or phenyl mono- or bisubstituted with methyl, methoxy-group, F, Cl or CF₃-group and their physiologically acceptable salts. Compounds show antiarrhythmic properties and act as inhibitors of cellular Na⁺/H⁺-anticarrier. Invention describes also method of their synthesis, pharmaceutical composition and method of its preparing. EFFECT: new compounds indicated above, improved method of synthesis and preparing, valuable pharmacological properties. 8 cl, 10 ex