METHOD OF SYNTHESIS OF 3-N,N-DICYCLOBUTYLAMINO-8- -FLUORO-3,4- DIHYDRO-2H-1-BENZOPYRANE-5-CARBOXAMIDE AS RACEMIC COMPOUND OR R- OR S-ENANTIOMERS AND INTERMEDIATE COMPOUNDS Russian patent published in 2002 - IPC

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to novel method of synthesis of 3-N,N-dicyclobutylamino-8 -fluoro-3,4-dihydro-2H-1-benzopyrane-5- carboxamide as racemic compound or R- and S-enantiomers of the formulas: (I) , R-(I) and S-(I) and their pharmaceutically acceptable salts and also to intermediate compounds synthesized and used in indicated method of the formulas: (V) , (VII) , (VIII) , (IX) and (X) . Method excludes fluorination stages and by-side product preparing by means of the use of compound comprising fluoro-substitute in required position as the parent compound. EFFECT: improved method of synthesis, simplified process. 16 cl, 11 ex