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2 169 770

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Application

2000114544/13, 2000-06-09

(24)

Start date

2000-06-09

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Actual filing date

2000-06-09

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Published

2001-06-27

(72)

Inventor

Saljanov V.I.Skuridin S.G.Evdokimov Ju.M.

(73)

Holder

Institut Molekuljarnoj Biologii Im. V.A. Ehngel'Gardta Ran

MESOMORPHIC DISPERSION BASED ON COMPLEX NUCLEIC ACID-CHITISAN AS INTEGRAL BIOSENSOR AND METHOD OF ITS DEVELOPMENT Russian patent published in 2001 - IPC

Abstract RU 2169770 C1

FIELD: biotechnology. SUBSTANCE: lyotropic cholesteric mesomorphic dispersion as an integral biosensor for assay of biologically active substances in liquid to be analyzed is prepared. This dispersion is a complex of double-stranded nucleic acid molecules with chitosan in an aqueous-saline solution with physiological ionic strength value. Complex has anthracycline antibiotic additionally. Dispersion is prepared by mixing chitosan an aqueous solution and an aqueous-saline solution of nucleic acid to form chitosan "cross-links" fixing nucleic acid molecules in dispersion composition that shows intensive band in circular dichroism spectrum at λ about 270 nm. EFFECT: improved method of dispersion preparing. 7 cl, 5 dwg, 4 ex

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RU 2 169 770 C1

Authors

Saljanov V.I.

Skuridin S.G.

Evdokimov Ju.M.

Dates

2001-06-27—Published

2000-06-09—Filed

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