Show metadata Hide metadata

(19)

(11)

2 281 946

(13)

(51)

IPC

C07D417/04(2006-01-01)

C07D285/16(2006-01-01)

A61K31/549(2006-01-01)

A61P31/12(2006-01-01)

(21) (22)

Application

2005129447/04, 2005-09-21

(24)

Start date

2005-09-21

(22)

Actual filing date

2005-09-21

(45)

Published

2006-08-20

(72)

Inventor

Chupakhin Oleg NikolaevichSidorova Larisa PetrovnaRusinov Vladimir LeonidovichBelanov Evgenij FedorovichBalakhnin Sergej MarkovichBormotov Nikolaj IvanovichSandakhchiev Lev Stepanovich

(73)

Holder

Gou Vpo Ural'Skij Gosudarstvennyj Tekhnicheskij Universitet-Upi

2-CYCLOALKYLIMINO-5-(4-NITROPHENYL)-1,3,4-THIADIAZINES POSSESSING BIOLOGICAL ACTIVITY AGAINST SMALLPOX VIRUS Russian patent published in 2006 - IPC C07D417/04 C07D285/16 A61K31/549 A61P31/12

Abstract RU 2281946 C1

FIELD: organic chemistry, medicine, virology.

SUBSTANCE: invention relates to novel 2-cycloalkylimino-5-(4-nitrophenyl)-1,3,4-thiadiazines of the general formula (I): wherein the group represents: piperidino-, pyrrolidino-, methylpiperazino-, hexamethyleneimino-group that possess the biological activity against smallpox virus. Invention provides preparing novel biological active compounds possessing an antiviral effect, in particular, against smallpox virus.

EFFECT: valuable biological and medicinal properties of compounds.

1 cl, 1 tbl, 4 ex

Similar patents RU2281946C1

Title	Year	Author	Number
SUBSTITUTED 6H-1,3,4-THIADIAZINE-2-AMINES, THEIR USE AS ANESTHETIC, CARDIOVASCULAR AND HYPOMETABOLIC AGENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF	1995	Chupakhin O.N.(Ru) Sidorova L.P.(Ru) Tarakhtij Eh.A.(Ru) Novikova A.P.(Ru) Perova N.M.(Ru) Vinogradov V.A.(Ru) Mishel' Frantsiskus Van Ginkel'	RU2157210C2
SUBSTITUTED 5R,6R -1,3,4-THIADIAZINE-2-AMINES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOF AS PHARMACOLOGICALLY ACTIVE AGENTS ELICITING ANTICOAGULANT AND ANTI-AGGREGATING EFFECT	2003	Chupakhin O.N. Sidorova L.P. Perova N.M. Charushin V.N. Rusinov V.L. Muljar A.G.	RU2259371C2
PHARMACEUTICALLY ACCEPTABLE SALTS OF SUBSTITUTED 6H-1,3,4- -THIADIAZINE-2-AMINES AND THEIR PHARMACEUTICAL COMPOSITIONS	1995	Chupakhin O.N.(Ru) Sidorova L.P.(Ru) Tarakhtij Eh.A.(Ru) Novikova A.P.(Ru) Perova N.M.(Ru) Vinogradov V.A.(Ru) Mishel' Frantsiskus Van Ginkel'	RU2152943C1
5-(4'-HYDROXYPHENYL)-AND 5-(2',5'-DIHYDROXYPHENYL)-6 H-1,3,4-THIADIAZINE-2-AMINES, HYDROHALOGENIDES INHIBITING THROMBOCYTE AGGREGATION IN INTRAVENOUS INTRODUCTION	2009	Chupakhin Oleg Nikolaevich Sidorova Larisa Petrovna Petrova Natal'Ja Mikhajlovna Novikova Antonina Petrovna Rusinov Vladimir Leonidovich Makarov Vladimir Aleksandrovich Vasil'Eva Tat'Jana Mikhajlovna	RU2458060C2
2-CYCLOALKYLAMINO-5-THIENYL-1,3,4-THIADIAZINES, HYDROBROMIDES, WITH ANTIAGGREGANT ACTIVITY	2008	Chupakhin Oleg Nikolaevich Sidorova Larisa Petrovna Perova Natal'Ja Mikhajlovna Rusinov Vladimir Leonidovich Makarov Vladimir Aleksandrovich Vasil'Eva Tat'Jana Mikhajlovna Vorob'Ev Andrej Ivanovich	RU2379306C1
1-HYDROXY- AND 1-METHOXY-2-(4-NITROPHENYL)IMIDAZOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY AGAINST ORTHOPOXVIRUSES	2022	Basanova Elizaveta Ivanovna Nikitina Polina Andreevna Perevalov Valerii Pavlovich Shishkina Larisa Nikolaevna Bormotov Nikolai Ivanovich Serova Olga Alekseevna Mazurkov Oleg Iurevich	RU2794763C1
2-PIPERIDINO-5-(THIENYL-2)- AND 2-PIPERIDINO-5-(THIENYL-3)- 6H-1,3,4-THIADIAZINES HYDROBROMIDES POSSESSING ANTIAGGREGANT ACTION	2010	Chupakhin Oleg Nikolaevich Sidorova Larisa Petrovna Perova Natal'Ja Mikhajlovna Rusinov Vladimir Leonidovich Makarov Vladimir Aleksandrovich Vasil'Eva Tat'Jana Mikhajlovna	RU2445310C2
2-AMINOPROPYLMORPHOLINO-5-ARYL-6H-1,3,4-THIADIAZINES, DIHYDROBROMIDES AND 2-AMINOPROPYLMORPHOLINO-4-ARYLTHIAZOLES, HYDROBROMIDES SHOWING ANTIAGGREGANT ACTION	2011	Chupakhin Oleg Nikolaevich Sidorova Larisa Petrovna Perova Natal'Ja Mikhajlovna Rusinov Vladimir Leonidovich Makarov Vladimir Aleksandrovich Logvinova Julija Sergeevna Vasil'Eva Tat'Jana Mikhajlovna	RU2456284C1
ANTIVIRAL AGENT	2009	Selivanov Boris Alekseevich Tikhonov Aleksej Jakovlevich Belanov Evgenij Fedorovich Bormotov Nikolaj Ivanovich Balakhnin Sergej Markovich Serova Ol'Ga Alekseevna Svjatchenko Viktor Aleksandrovich Kiselev Nikolaj Nikolaevich Kazachinskaja Elena Ivanovna Loktev Valerij Borisovich Drozdov Il'Ja Gennadievich Stavskij Evgenij Aleksandrovich	RU2423359C1
HEPATITIS B VIRUS (HBV) INHIBITOR, WHICH IS A DERIVATIVE OF N-{3-[6-(DIALKYLAMINO)PYRIDAZINE-3-YL]PHENYL}ARYL SULPHONAMIDE DERIVATIVES AND DERIVATIVES OF N-{4-[6-(DIALKYLAMINO)PYRIDAZINE-3-YL]PHENYL}ARYL SULPHONAMIDE	2019	Ivashchenko Andrej Aleksandrovich Ivashchenko Aleksandr Vasilevich Savchuk Nikolaj Filippovich Mitkin Oleg Dmitrievich Kravchenko Dmitrij Vladimirovich Kovalenko Sergej Nikolaevich Bunyatyan Natalya Dmitrievna	RU2738848C1

RU 2 281 946 C1

Authors

Chupakhin Oleg Nikolaevich

Sidorova Larisa Petrovna

Rusinov Vladimir Leonidovich

Belanov Evgenij Fedorovich

Balakhnin Sergej Markovich

Bormotov Nikolaj Ivanovich

Sandakhchiev Lev Stepanovich

Dates

2006-08-20—Published

2005-09-21—Filed