FIELD: organic chemistry, antibiotics.
SUBSTANCE: invention relates to novel compounds of carbapenem chosen from the following compounds: 1-ethylpropyloxycarbonyloxymethyl-(1R,5S,6S)-2-[(3S,5S)-(5-N,N-dimethylaminocarbonyl-1-isobutyryloxymethyloxycarbonyl)pyrrolidine-3-ylthio]-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate, 1-ethylpropyloxycarbonyloxymethyl-(1R,5S,6S)-2-[(3S,5S)-(5-N,N-dimethylaminocarbonyl-1-butyryloxymethyloxycarbonyl)pyrrolidine-3-ylthio]-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate, 1-ethylpropyloxycarbonyloxymethyl-(1R,5S,6S)-2-[(3S,5S)-(5-N,N-dimethylaminocarbonyl-1-propionyloxymethyloxycarbonyl)pyrrolidine-3-ylthio]-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate, cyclohexyloxycarbonyloxymethyl-(1R,5S,6S)-2-[(3S,5S)-(5-N,N-dimethylaminocarbonyl-1-ixobutyryloxymethyloxycarbonyl)pyrrolidine-3-ylthio]-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate, cyclohexyloxycarbonyloxymethyl-(1R,5S,6S)-2-[(3S,5S)-(5-N,N-dimethylaminocarbonyl-1-butyryloxymethyloxycarbonyl)pyrrolidine-3-ylthio]-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate, cyclopentyloxycarbonyloxymethyl-(1R,5S,6S)-2-[(3S,5S)-(5-N,N-dimethylaminocarbonyl-1-isobutyryloxymethyloxycarbonyl)pyrrolidine-3-ylthio]-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate or cyclopentyloxycarbonyloxymethyl-(1R,5S,6S)-2-[(3S,5S)-(5-N,N-dimethylaminocarbonyl-1-butyryloxymethyloxycarbonyl)pyrrolidine-3-ylthio]-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate. Enumerated compounds can be used as an active component in antibacterial agent used by oral route administration.
EFFECT: valuable medicinal properties of compounds.
2 cl, 5 tbl, 15 ex
| Title | Year | Author | Number |
|---|---|---|---|
| CARBAPENEM DERIVATIVE, ANTIBACTERIAL AGENT BASED ON IT, AND ITS INTERMEDIATE | 1998 |
|
RU2178792C2 |
| DERIVATIVES OF CARBAPENEM, THEIR USING AND INTERMEDIATE COMPOUNDS FOR THEIR PREPARING | 1999 |
|
RU2222540C2 |
| CARBOPENEM DERIVATIVES AND A METHOD OF THEIR SYNTHESIS | 1993 |
|
RU2097383C1 |
| CRYSTALLINE DERIVATIVES OF 1-METHYLCARBAPENEM | 2000 |
|
RU2214411C2 |
| METHOD OF PRODUCING CARBAPENEM DERIVATIVES OR THEIR 4-NITROBENZYL ESTERS | 0 |
|
SU1501922A3 |
| 1-METHYLCARBAPENEM OR ITS PHARMACOLOGICALLY ACCEPTABLE SALTS, COMPOSITION, METHOD OF PROPHYLAXIS OR TREATMENT OF PATIENT WITH BACTERIAL INFECTION | 1997 |
|
RU2162088C2 |
| 1-METHYLCARBAPENAM DERIVATIVES | 2001 |
|
RU2247725C2 |
| 1-METHYLCARBAPENEM DERIVATIVES, METHOD OF PREPARING THEREOF, PHARMACEUTICAL COMPOSITION BASED THEREON, AND METHOD OF ANTIBACTERIAL EFFECT | 1996 |
|
RU2160737C2 |
| METHOD FOR OBTAINING INTERMEDIATE ERTAPENEM COMPOUND | 2010 |
|
RU2575979C2 |
| CARPAPENEM DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | 1992 |
|
RU2091381C1 |
