FIELD: chemistry.
SUBSTANCE: invention relates to novel compounds - 5-[3-(4-benzyloxyphenylthio)-fur-2-yl]-imidazolidine-2,4-diones and their formula (IV) or pharmaceutically acceptable salts thereof 
, where R is selected from a group consisting of phenyl, 4-benzyloxyphenyl, 4-diphenyl, 4-methoxyphenyl, 3-methoxyphenyl, 2-methoxyphenyl, 3,5-dimethoxyphenyl, 4-chlorophenyl, 3-chlorophenyl, 2-chlorophenyl, 4-methylphenyl, 3-methylphenyl, 2-methylphenyl and 3-trifluoromethylphenyl, useful as human microphage elastase (MMP-12) inhibitors, as well as pharmaceutical compositions based on the said compounds and inhibition method.
EFFECT: obtaining compounds useful as human microphage elastase (MMP-12) inhibitors, as well as design of pharmaceutical compositions based on the said compounds and inhibition method.
6 cl, 1 dwg,1 tbl, 1 ex
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