FIELD: medicine.
SUBSTANCE: invention belongs to microbiology and biotechnology, notably to tuberculosis anatoxin manufacture for specific prevention of tuberculosis. Tuberculosis anatoxin is made by detoxication of tuberculosis exo- and endotoxins with two detoxifiers - 0.2% formalin solution during 7-9 days at 42-45 C° and 0.5% aethonium solution during 7-9 days at 42-45 C°. Then tuberculosis anatoxin is sorbed on 1-3 mg/ml of aluminium hydroxide, concentration of inactivated toxic allergens is doubled by decantation of 50±5% of supernatant.
EFFECT: usage of anatoxin manufactured by this method gives vaccinated animals immunity to induced by virulent tuberculosis mycobacterium infection due to immune reorganisation of organism; animals acquire moderate sensibility to tuberculin.
4 ex
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